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Amphetamine is thought to inhibit monoamine oxidase, whereas the ability of amphetamine and its metabolites to inhibit numerous P450 isozymes as well as other enzymes has not been sufficiently elucidated. In vitro experiments with human microsomes indicate minor inhibition of CYP2D6 by amphetamine and minor inhibition of CYP1A2, 2D6, and 3A4 by one